Two workers at the Somerset base of luxury fashion brand Mulberry contracted with tuberculosis within months of each other.
Staff working at The Rookery factory in Chilcompton have been screened for the disease.
A statement from Mulberry said: "The first was diagnosed in January 2014 and returned to work fully recovered three weeks later. The second employee was diagnosed in May 2014 and is due to return to work shortly.
"Mulberry has fully complied with Public Health England advice on this."
Public Health England (PHE) said both workers are currently on treatment, recovering well and are not infectious.
Dr Sarah Harrison, interim deputy director of health protection for the Devon, Cornwall and Somerset PHE Centre said: "First and foremost, it is important to stress that TB is difficult to catch. It is spread from person to person when an infectious person has a cough. The people who are most at risk are those living in the same household.
"It is important to remember that TB is a curable disease which can be treated effectively with antibiotics, particularly if found early.
"Letters from Public Health England have been sent to
all staff that were tested. Those with a positive test have been referred to local TB services for further investigation and treatment if necessary. The general advice is that people should contact their doctor if they are suffering from the symptoms of TB."
As a precautionary measure following these confirmed cases, PHE offered TB screening to more than 420 staff at the factory; over 300 people have been screened.
Those who tested positive will be referred to the specialist service for further testing with specialist respiratory physicians.
A positive screen result does not necessarily mean that they have infectious TB or TB disease. In most instances a positive result implies the presence of latent TB.
A positive latent TB test means that someone has had exposure to the TB bacteria at some time in their life, not necessarily through this incident. Positive tests could have been caused by a source case within the factory community or alternatively, there may be a previous source of exposure.
TB is a disease caused by a bacterial infection. It can be treated with antibiotics. Fortunately, it is not easily passed from person to person and generally the risk to others is low.